HONG Xianjian, HU Ruiling, CAI Xupeng, et al. Preparation of ZnFe2O4@ZIF-8@Ag nanocomposites and their antibacterial properties[J]. Acta Materiae Compositae Sinica.
Citation: HONG Xianjian, HU Ruiling, CAI Xupeng, et al. Preparation of ZnFe2O4@ZIF-8@Ag nanocomposites and their antibacterial properties[J]. Acta Materiae Compositae Sinica.

Preparation of ZnFe2O4@ZIF-8@Ag nanocomposites and their antibacterial properties

  • The extensive utilization of antibiotics has led to a gradual escalation in bacterial resistance, particularly the emergence of multidrug-resistant strains. This phenomenon poses significant challenges to conventional antibiotic treatments. In addressing this challenge, the present study proposes a novel approach, which involves the synthesis of magnetic zinc ferrate (ZnFe2O4) through a hot solvent method, employing FeCl3 and ZnCl2 as primary reagents. This method involves the coating of ZIF-8 on the surface of ZnFe2O4, resulting in the formation of ZnFe2O4@ZIF-8 nanorods. Subsequently, silver nanoparticles with an average particle size of 8 nm are loaded onto the surface of ZnFe2O4@ZIF-8 through an adsorption method. Finally, ZnFe2O4@ZIF-8@Ag nanocomposites were prepared by loading silver nanoparticles (Ag NPs) with an average particle size of 8 nm on the surface by adsorption.The structure and properties of the composites were systematically characterized using transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometer (VSM). The bacteriostatic activity, mechanism of inhibition, and pro-infectious wound healing activity of the composites were examined using Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus), and drug-resistant Salmonella (T-Salmonella) as test organisms.Furthermore, the healing rate of trauma in mice reached 95.2% within 10 days. The study on the mechanism of bacterial inhibition revealed that the nanocomposite material induced the leakage of substances and ions withinthe bacterial cells by disrupting the bacterial cell wall and cell membrane.This disruption results in the leakage of intracellular substances and ions, subsequently causing an imbalance in osmotic pressure, which ultimately leads to bacterial death.
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