Abstract: Graphene-reinforced high-entropy alloy matrices effectively mitigate wear-induced damage in micro/nano-devices during service. Nevertheless, the atomic-scale tribological mechanisms of graphene/high-entropy alloys systems remain incompletely understood. This study employs molecular dynamics simulations to investigate the influence of graphene layer number on the tribological performance. Key findings reveal that increasing graphene layers concurrently reduces the friction coefficient and wear atom count while delaying surface plastic deformation initiation. Specifically, five-layer graphene decreases the friction coefficient by 91.46% and reduces wear atoms by 94.19% compared to pure HEA. Furthermore, adsorbed graphene coatings trigger extensive dislocation nucleation and multiplication, intensifying subsurface damage and promoting HCP phase transformation. Shear strain analysis demonstrates that graphene coatings significantly expand surface strain distribution areas while homogenizing strain fields. This restructuring of stress distribution extends shear strain propagation into the substrate's far-field regions.