Abstract: Nanozymes derived from metal-organic frameworks (MOFs) are synthetic enzymes with adjustable porosity, high specific surface area, modifiable surfaces, and catalytic properties that emulate natural enzymes. Gold nanoparticle (AuNPs) modified MOFs (AuNPs@MOFs composites) form a significant category of MOF-based nanozymes. Importantly, the localized surface plasmon resonance effects of AuNPs enhance the nanozymes properties of AuNPs@MOFs composites and expand their application potential, which have garnered substantial research attention in recent years. This review focuses on the summarizing of the synthetic protocols of AuNPs@MOFs composites, their enzyme-like activities (such as peroxidase-like, oxidase-like and catalase-like), their advancements in bio-sensing and anticancer, and discussing their future prospects.