Abstract: The extensive utilization of antibiotics has led to a gradual escalation in bacterial resistance, particularly the emergence of multidrug-resistant strains. This phenomenon poses significant challenges to conventional antibiotic treatments. In addressing this challenge, the present study proposes a novel approach, which involves the synthesis of magnetic zinc ferrate (ZnFe₂O₄) through a hot solvent method, employing FeCl₃ and ZnCl₂ as primary reagents. This method involves the coating of ZIF-8 on the surface of ZnFe₂O₄, resulting in the formation of ZnFe₂O₄@ZIF-8 nanorods. Subsequently, silver nanoparticles with an average particle size of 8 nm are loaded onto the surface of ZnFe₂O₄@ZIF-8 through an adsorption method. Finally, ZnFe₂O₄@ZIF-8@Ag nanocomposites were prepared by loading silver nanoparticles (Ag NPs) with an average particle size of 8 nm on the surface by adsorption.The structure and properties of the composites were systematically characterized using transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometer (VSM). The bacteriostatic activity, mechanism of inhibition, and pro-infectious wound healing activity of the composites were examined using Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus), and drug-resistant Salmonella (T-Salmonella) as test organisms.Furthermore, the healing rate of trauma in mice reached 95.2% within 10 days. The study on the mechanism of bacterial inhibition revealed that the nanocomposite material induced the leakage of substances and ions withinthe bacterial cells by disrupting the bacterial cell wall and cell membrane.This disruption results in the leakage of intracellular substances and ions, subsequently causing an imbalance in osmotic pressure, which ultimately leads to bacterial death.