Abstract: To enhance the photocatalytic performance of CdS nanoparticles (CdSNPs), Au/UIO-66-NH₂/CdS catalysts were successfully prepared by the combination of hydrothermal method, solvothermal method, photoreduction method, and in-situ growth method. The basic properties of the catalysts including phase composition, morphology, and optical properties were analyzed using techniques such as XRD, SEM, TEM, BET, and EIS. Furthermore, the efficiency and stability of methylene blue (MB) degradation under visible light were investigated in detail. The results indicate that CdSNPs and Au nanoparticles (AuNPs) are dispersed uniformly on the surface of the regular octahedral structure of UIO-66-NH₂, without obvious agglomeration between nanoparticles. Au/UIO-66-NH₂/CdS possesses higher interfacial charge transfer, electron-hole separation efficiency, and visible light absorption ability than the pure CdSNPs. More importantly, Au_1.0/UIO-66-NH₂/CdS exhibits the optimal photocatalytic degradation activity for MB, reaching up to 93.8%, which is six times higher than that of pure CdSNPs. Meanwhile, after undergoing 5 cycles of experiments, the degradation rate of Au/UIO-66-NH₂/CdS remains above 83%, indicating its favorable cyclic stability.